Sarcoidosis treated with chloroquine
Identifieur interne : 003E28 ( Main/Exploration ); précédent : 003E27; suivant : 003E29Sarcoidosis treated with chloroquine
Auteurs : D. Davies [Royaume-Uni]Source :
- British Journal of Diseases of the Chest [ 0007-0971 ] ; 1963.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical : Chloroquine.
- Teeft :
- Biopsy, Bronchial biopsy, Bronchial obstruction, Bronchial tree, Bronchogram, Chloroquine, Chloroquine sulphate, Conjunctival biopsy, Corticosteroid, Epithelioid cell follicles, February, Follicle, Giant cells, Hilar nodes, Humans, Lobe, Lower lobe, Lower trachea, Lung Diseases, Lung fields, Lung lesions, Misty vision, More fibrosis, Mottling, Node, November, Patchy shadowing, Pulmonary sarcoidosis, Right bronchogram, Safer alternative, Sarcoid follicles, Sarcoidosis, Scalene node biopsy, Segmental bronchi, Skin lesions, Spontaneous regression, Sulphate, Table tests, Troublesome cough, Tuberculin skin test, Upper lobe, Upper lobe orifice, Upper zones, Ventilatory tests.
Abstract
Summary: Though the majority of patients with sarcoidosis need no treatment, some do because of the development of pulmonary fibrosis, bronchial obstruction or eye and skin lesions. The only well-tried treatment is the use of corticosteroids, which are attended by side effects and risks when continued for long periods.Five cases of pulmonary sarcoidosis, in which spontaneous regression was not expected, were treated with chloroquine. The drug produced or maintained regression of the lesions, but the effect may have been suppressive rather than curative. It may prove to be a better and safer alternative than corticosteroids.Bleaching of the hair appears to be an inevitable side effect and watch should be kept for eye complications.
Url:
DOI: 10.1016/S0007-0971(63)80005-4
Affiliations:
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Le document en format XML
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<term>Bronchial obstruction</term>
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<term>Chloroquine</term>
<term>Chloroquine sulphate</term>
<term>Conjunctival biopsy</term>
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<term>More fibrosis</term>
<term>Mottling</term>
<term>Node</term>
<term>November</term>
<term>Patchy shadowing</term>
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<term>Spontaneous regression</term>
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<term>Troublesome cough</term>
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<term>Upper zones</term>
<term>Ventilatory tests</term>
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<front><div type="abstract" xml:lang="en">Summary: Though the majority of patients with sarcoidosis need no treatment, some do because of the development of pulmonary fibrosis, bronchial obstruction or eye and skin lesions. The only well-tried treatment is the use of corticosteroids, which are attended by side effects and risks when continued for long periods.Five cases of pulmonary sarcoidosis, in which spontaneous regression was not expected, were treated with chloroquine. The drug produced or maintained regression of the lesions, but the effect may have been suppressive rather than curative. It may prove to be a better and safer alternative than corticosteroids.Bleaching of the hair appears to be an inevitable side effect and watch should be kept for eye complications.</div>
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